PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Ethyl 2-(3-chloropropoxy)acetate
0 ImagesCat. No.: HY-W109722CAS No.: 143165-48-4
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N1-Benzyl-N1-methylethane-1,2-diamine
0 ImagesCat. No.: HY-W098607CAS No.: 14165-18-5
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PEG2-C-NH2
0 ImagesCat. No.: HY-W043937CAS No.: 99513-01-6
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Benzyl 4-((2-aminoethoxy)methyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W618963CAS No.: 1353961-56-4
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Hydroxy-PEG3-ethyl ester
0 ImagesCat. No.: HY-W130007CAS No.: 1379649-80-5
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10-(Benzyloxy)-10-oxodecanoic acid
0 ImagesCat. No.: HY-W108237CAS No.: 67852-88-4
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Boc-MeN-C5-OH
0 ImagesCat. No.: HY-W369104CAS No.: 1338075-62-9
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tert-Butyl (4-hydroxybicyclo[2.2.2]octan-1-yl)carbamate
![tert-Butyl (4-hydroxybicyclo[2.2.2]octan-1-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w056046.gif "Click to View tert-Butyl (4-hydroxybicyclo[2.2.2]octan-1-yl)carbamate Product Detail")
0 ImagesCat. No.: HY-W056046CAS No.: 1252672-84-6
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(9H-Fluoren-9-yl)methyl (4-aminobutyl)carbamate
0 ImagesCat. No.: HY-W574000CAS No.: 117048-49-4
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17-Methoxy-17-oxoheptadecanoic acid
0 ImagesCat. No.: HY-W460256CAS No.: 72849-42-4
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Methyl 6-aminohexanoate
0 ImagesCat. No.: HY-W357367CAS No.: 2780-89-4
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trans-1,4-Cyclohexanedicarboxylic acid
0 ImagesCat. No.: HY-W016897CAS No.: 619-82-9
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Octa-1,7-diyne
0 ImagesCat. No.: HY-W267762CAS No.: 871-84-1
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tert-Butyl 20-bromoicosanoate
0 ImagesCat. No.: HY-W614704CAS No.: 1642333-07-0
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1-Boc-4-(4-Carboxybenzyl)piperazine
0 ImagesCat. No.: HY-W102044CAS No.: 479353-63-4
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6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate
![6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate](https://file.medchemexpress.com/product_pic/hy-w058292.gif "Click to View 6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate Product Detail")
0 ImagesCat. No.: HY-W058292CAS No.: 203662-61-7
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N1,N4-Dimethylbutane-1,4-diamine
0 ImagesCat. No.: HY-W088621CAS No.: 16011-97-5
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tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W102095CAS No.: 138227-63-1
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Thalidomide-O-PEG4-acid
0 ImagesCat. No.: HY-W800655CAS No.: 2446382-02-9Thalidomide-O-PEG4-Acid is a PROTAC linker that can react with Amine containing moiety in the presence of Activator EDC or HATU.
